Study Suggests DMT May Effectively Treat Depression

el-balad.com · Feb 17, 2026 · Collected from GDELT

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Recent research indicates that dimethyltryptamine (DMT) may provide an effective treatment for depression. A study conducted in the UK involved a small, randomized, placebo-controlled trial focusing on individuals with major depression. The findings suggest that DMT could offer a rapid improvement in depressive symptoms, lasting at least 12 weeks. Study Overview The study was published in the journal Nature Medicine and involved 34 participants diagnosed with moderate to severe depression. The researchers administered DMT alongside psychotherapy to half of the participants while the rest received a placebo. Results and Findings Participants who received DMT reported significantly fewer depression symptoms compared to those who received a placebo. Once the placebo group took DMT, they also experienced a reduction in their depressive symptoms. By the three-month mark, 47% of all participants had improved enough to be considered in remission. Both groups maintained a noticeable level of improvement for at least three months, with some participants seeing sustained effects up to six months. DMT’s Unique Properties DMT’s effects tend to be much shorter lived compared to other psychedelic substances, with a half-life of around five minutes. This characteristic may allow for quicker, more cost-effective therapy sessions, particularly when combined with appropriate therapeutic support. Safety and Side Effects The study reported that DMT was safe and well-tolerated among participants. Common side effects included: Pain at infusion sites Nausea Transient anxiety No serious adverse events were documented during the trial. Future Research Directions While these initial findings are promising, the researchers noted that larger trials are necessary to validate DMT’s efficacy, safety, and cost-effectiveness compared to existing treatments. Current research efforts are underway to further investigate DMT and its potential applications in various mental health conditions. The Road Ahead for Psychedelic Treatments Despite encouraging results, the path towards the approval of DMT for depression treatment remains complex. Recent regulatory challenges highlight the need for additional positive data before DMT can be considered a standard psychiatric treatment. As the field of psychedelic medicine evolves, continued research will be crucial to understand the full potential of DMT and other similar substances in mental health therapy.