Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer

Nature News · Feb 18, 2026 · Collected from RSS

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CLINICAL BRIEFINGS 18 February 2026 In an experimental trial, a personalized mRNA vaccine was tested in 14 individuals with an aggressive form of breast cancer. It trained immune cells to target cancer-specific mutant proteins, inducing strong, lasting immunity. Ten participants remained disease-free. Analysis of relapses revealed resistance mechanisms, offering essential insights for future therapies. This is a summary of: Sahin, U. et al. Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC. Nature https://doi.org/10.1038/s41586-025-10004-2 (2026). Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support doi: https://doi.org/10.1038/d41586-026-00477-0Figure 1 is published under a CC BY 4.0 licence. ReferencesLi, X. et al. Breast Cancer Res. Treat. 161, 279–287 (2017).Article PubMed Google Scholar Sahin, U. et al. Nature 547, 222–226 (2017).Article PubMed Google Scholar Vormehr, M. et al. Annu. Rev. Med. 70, 395–407 (2019).Article PubMed Google Scholar Rojas, L. A. et al. Nature 618, 144–150 (2023).Article PubMed Google Scholar Kranz, L. M. et al. Nature 534, 396–401 (2016).Article PubMed Google Scholar Download references Related Articles Read the paper: Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC A personalized cancer vaccine to prevent the return of high-risk kidney cancer Bespoke vaccines can elicit long-lived immune activity against pancreatic cancer Subjects Latest on: Health care Vaccines Cancer An agentic system for rare disease diagnosis with traceable reasoning Article 18 FEB 26 In vivo base editing of Chd3 rescues behavioural abnormalities in mice Article 18 FEB 26 Updates to the ‘bible’ for mental-health conditions will miss the mark — is it time to ditch the DSM? World View 17 FEB 26 Mucosal vaccination clears Clostridioides difficile colonization Article 18 FEB 26 How some COVID vaccines triggered rare blood-clot disorder News 12 FEB 26 What drugs are safe during pregnancy? There’s a shocking lack of data News Feature 11 FEB 26 The integrated stress response promotes immune evasion through lipocalin 2 Article 18 FEB 26 AI offers way to image and assess clinical cell samples News & Views 18 FEB 26 Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC Article 18 FEB 26