Parkinson’s disease affects network of brain regions that controls whole-body action

Nature News · Feb 25, 2026 · Collected from RSS

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RESEARCH BRIEFINGS 25 February 2026 Precision brain imaging of individuals with Parkinson’s disease reveals that the affected circuit is best characterized as a previously described network of brain regions called the somato-cognitive action network. Abnormally high connectivity in this network is associated with Parkinson’s disease and is normalized by effective pharmacological treatment and various brain-stimulation therapies. This is a summary of: Ren, J. et al. Parkinson’s disease as a somato-cognitive action network disorder. Nature https://doi.org/10.1038/s41586-025-10059-1 (2026). Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 € / 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access 185,98 € per year only 3,65 € per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support doi: https://doi.org/10.1038/d41586-026-00573-1‘Expert opinion’ is published under a CC BY 4.0 licence, Figure 1 is published under a CC BY-NC-ND 4.0 licence. ReferencesSveinbjornsdottir, S. J. Neurochem. 139, 318–324 (2016).Article PubMed Google Scholar Gordon, E. M. et al. Nature 617, 351–359 (2023).Article PubMed Google Scholar Shen, L. et al. Ann. Neurol. 88, 1178–1193 (2020).Article PubMed Google Scholar Dahmani, L. et al. npj Parkinsons Dis. 9, 90 (2023).Article PubMed Google Scholar Ren, J. et al. Brain Stimul. 16, 1313–1321 (2023).Article PubMed Google Scholar Download references Related Articles Read the paper: Parkinson’s disease as a somato-cognitive action network disorder Clinical trials test the safety of stem-cell therapy for Parkinson’s disease Tracing the brain circuitry underlying movement and mood symptoms in Parkinson’s disease Subjects Latest on: Brain Neuroscience Brains of ‘super agers’ are still strong producers of new neurons News 25 FEB 26 Blood test holds promise for predicting when Alzheimer’s symptoms will start News 19 FEB 26 How do autistic people age — and what does it mean for their health? News Feature 18 FEB 26 Compact deep neural network models of the visual cortex Article 25 FEB 26 Vectorized instructive signals in cortical dendrites Article 25 FEB 26 Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease Article 25 FEB 26