Neanderthal DNA study reveals surprising partner preference

independent.co.uk · Feb 27, 2026 · Collected from GDELT

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A new genetic analysis has offered a fascinating glimpse into the ancient encounters between humans and Neanderthals, suggesting a surprising pattern in their interbreeding. While it has long been understood that the two groups coexisted and occasionally "cozied up" tens of thousands of years ago, fresh research indicates that pairings were more frequently between female humans and male Neanderthals.This intriguing discovery raises significant questions about the nature of these prehistoric interactions. Researchers are now pondering how such unions occurred: did human women venture into Neanderthal populations, or were Neanderthal males drawn to larger human enclaves? The exact dynamics remain a mystery, with questions lingering over whether these encounters were peaceful, confusing, secretive, or even violent."I don’t know if we’ll ever get a definitive answer to how this happened, since we can’t travel back in time," commented population genetics expert Xinjun Zhang from the University of Michigan, underscoring the enduring challenge of fully comprehending these ancient relationships.There is a surprising lack of Neanderthal DNA in the human X chromosome (AP Photo/Martin Meissner)But the study, published Thursday in the journal Science, shows “that whenever Neanderthals and modern humans have mated, there has been a preference for male Neanderthals and female modern humans, as opposed to the other way around,” said author Alexander Platt, who studies genetics at the University of Pennsylvania.Scientists know that Neanderthals and humans mated because there is a small but important percentage of Neanderthal DNA in most modern humans outside of sub-Saharan Africa — including genes that can help us fight some diseases and make us more susceptible to others. But they have also known that the Neanderthal DNA is not distributed evenly throughout the human genome.In particular, there is a surprising lack of Neanderthal DNA in the human X chromosome, one of the bundles of genes in each cell known as a sex chromosome, compared with the amount of Neanderthal DNA in the other, non-sex chromosomes in the cell. Scientists thought that maybe the genes in those locations were simply not beneficial – or even harmful. Perhaps people with those gene patterns didn’t survive as well so those genes were filtered out by evolution over time.Or, they thought, maybe the difference could be explained by how the two species intermingled.To try to solve the riddle, Platt and colleagues looked instead at the Neanderthal genome and the human DNA that got interspersed during a “mating event” 250,000 years ago. When comparing these genes, they found more of a human fingerprint on the Neanderthal X chromosome – the same chromosome that, in humans, has less Neanderthal DNA than would be expected.The most likely explanation for this mirror image pattern is mating behavior. That's because of the way sex chromosomes are passed from parents to children, explained Platt. Because genetic females have two X chromosomes and genetic males have one X and one Y chromosomes, two out of every three X chromosomes in a population, on average, are inherited from people’s mothers. If more human females mated with Neanderthal males than the other way around, over thousands of years you would expect to see just what they found: more human DNA in Neanderthal X chromosomes and less Neanderthal DNA in human X chromosomes. “I think that they’ve taken some really important steps in filling missing pieces to the puzzle,” said Joshua Akey, who studies evolutionary genomics at Princeton University and wasn't involved with the new study.The study can't totally rule out other explanations. For example, Zhang said, it’s possible that the offspring of human males and Neanderthal females just didn’t survive as well.But the simplest and most likely, explanation, the study found, is also the most interesting: “It’s not the result of a strictly Darwinian survival of the fittest,” Platt said. “It’s really the result of how we interact with each other, and what our culture and society and behavior is like.”