How an exercise-activated enzyme helps to keep the brain young

Nature News · Feb 25, 2026 · Collected from RSS

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RESEARCH HIGHLIGHT 25 February 2026 A protein reinforces the blood–brain barrier, which becomes leaky with age. An enzyme produced by liver cells (pictured) has anti-ageing effects on the brain. Credit: Biophoto Associates/Science Photo Library Exercise prevents brain ageing and memory loss by strengthening the blood–brain barrier, the structure that keeps harmful substances out of the brain1. Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 € / 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access 185,98 € per year only 3,65 € per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support doi: https://doi.org/10.1038/d41586-026-00515-x Subjects Latest on: Physiology CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly Article 25 FEB 26 CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis Article 25 FEB 26 Are obesity drugs causing a severe complication? What the science says News Explainer 20 FEB 26