Convergent MurJ flippase inhibition by phage lysis proteins

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Data availabilityAtomic coordinates of SglM–MurJ, SglPP7–MurJ and SglCJ3–MurJ are deposited at the Protein Data Bank (PDB) with accession codes 9NU4, 9NU5 and 9NU8, respectively. Cryo-EM maps of SglM–MurJ, SglPP7–MurJ and SglCJ3–MurJ are deposited at the Electron Microscopy Data Bank (EMDB) with accession codes EMDB-49796, EMDB-49797 and EMDB-49798, respectively. Source data are provided with this paper.Code availability The code used for microscopy analysis of lysis morphology is available from GitHub at https://github.com/AntillonF/bleb_statistical_analysis.git. ReferencesMurray, C. J. L. et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399, 629–655 (2022).Article CAS Google Scholar Naghavi, M. et al. Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050. Lancet 404, 1199–1226 (2024).Article Google Scholar Cook, M. A. & Wright, G. D. The past, present, and future of antibiotics. 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