Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

Nature News · Feb 26, 2026 · Collected from RSS

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Correction to: Nature https://doi.org/10.1038/s41586-025-09593-9 Published online 22 October 2025During the proof stage of this paper, the description of the statistical method in the legend for Fig. 4e was incorrectly edited to “Two-sided Fisher’s exact test, p value reported on graph.” The correct statistical method used, as stated during the peer review process, was a directional score test for equality of proportions using a Chi-square approximation. We have now corrected this in the figure legend to state “One-sided Chi-squared analysis, p value reported on graph.” We also note that the p value for comparison of WT to Tg animals is 0.036, not 0.032 as originally presented in the figure. The conclusions of this panel are unchanged.For Extended Data Fig. 9d, we note that the statistical tests performed and significance values of presented comparisons are shown correctly. To prevent confusion in interpreting our calculations, we have amended Extended Data Fig. 9d to include the results of Hmgn+/– genotype and the associated p value in comparison to WT animals (ns). The figure legend now includes total animals measured (n = 267) and significance value of WT and Hmgn+/– comparison (p = 0.8168).The Methods sections “MicroCT” and “Postnatal survival assay” have also been corrected to reflect these changes. All changes are included in the HTML and PDF versions of this article. Author informationAuthor notesSanjeev S. RanadePresent address: Center for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USASanjeev S. RanadePresent address: Center for Data Science and Artificial Intelligence, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USAThese authors contributed equally: Sanjeev S. Ranade, Feiya LiAuthors and AffiliationsGladstone Institutes, San Francisco, CA, USASanjeev S. Ranade, Feiya Li, Sean Whalen, Angelo Pelonero, Lin Ye, Yu Huang, Abigail Brand, Tomohiro Nishino, Rahul Mital, Frances Koback, Arun Padmanabhan, Victoria Yu, Alexander F. Merriman, Langley Grace Wallace, Annie Nguyen, Nikolaos Poulis, Mauro W. Costa, Casey A. Gifford, Katherine S. Pollard & Deepak SrivastavaRoddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA, USASanjeev S. Ranade, Feiya Li, Angelo Pelonero, Lin Ye, Yu Huang, Abigail Brand, Tomohiro Nishino, Rahul Mital, Frances Koback, Arun Padmanabhan, Victoria Yu, Alexander F. Merriman, Langley Grace Wallace, Annie Nguyen, Nikolaos Poulis, Mauro W. Costa, Casey A. Gifford & Deepak SrivastavaDepartment of Biomedical Engineering, Duke University, Durham, NC, USARyan M. BoileauCenter for Advanced Genomic Technologies, Duke University, Durham, NC, USARyan M. BoileauDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, USAArun PadmanabhanCardiovascular Research Institute, University of California, San Francisco, San Francisco, USAArun PadmanabhanCenter for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USABastien Cimarosti & Diana Presas-RamosCenter for Data Science and Artificial Intelligence, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USABastien Cimarosti & Diana Presas-RamosDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USACasey A. GiffordDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USACasey A. GiffordChan Zuckerberg Biohub, San Francisco, CA, USAKatherine S. PollardDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAKatherine S. PollardBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USAKatherine S. PollardInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USAKatherine S. PollardDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USADeepak SrivastavaDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USADeepak SrivastavaAuthorsSanjeev S. RanadeFeiya LiSean WhalenAngelo PeloneroLin YeYu HuangAbigail BrandTomohiro NishinoRahul MitalRyan M. BoileauFrances KobackArun PadmanabhanVictoria YuBastien CimarostiDiana Presas-RamosAlexander F. MerrimanLangley Grace WallaceAnnie NguyenNikolaos PoulisMauro W. CostaCasey A. GiffordKatherine S. PollardDeepak SrivastavaCorresponding authorsCorrespondence to Sanjeev S. Ranade or Deepak Srivastava.Rights and permissions Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. Reprints and permissionsAbout this articleCite this articleRanade, S.S., Li, F., Whalen, S. et al. Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21. Nature (2026). https://doi.org/10.1038/s41586-026-10283-3Download citationPublished: 26 February 2026Version of record: 26 February 2026DOI: https://doi.org/10.1038/s41586-026-10283-3